W głównej roli, jako Blanca Champion, wystąpiła w horrorze komediowym Killer Movie (2008).
Od 31 grudnia 2013 do maja 2016 była żoną tenisisty Ryana Sweetinga.
In 1999, Cuoco appeared on the CBS sitcom Ladies Man and in 2000 she portrayed former Brady Bunch star Maureen Mc Cormick in the TV movie Growing Up Brady.
In September 2002, Cuoco began a starring role as Bridget Hennessy on the ABC sitcom 8 Simple Rules.
Of course she did not disappoint her boyfriend and said yes! They got married on December 31, 2013 in California.
Executive producer Brad Kern stated Kaley's character was initially brought in as a possible spin-off.Kaley Christine Cuoco (formerly Sweeting, pronounced /ˈkeɪliː ˈkoʊkoʊ/; born November 30, 1985, Camarillo, California) is an American television actress.She is best known for her roles as Bridget Hennessy on the sitcom 8 Simple Rules, Brandy Harrington on Brandy & Mr. I was with my mom and my sister, but no one called, only two of my friends called. Did you ever wonder who dated hot actress Kaley Cuoco after she broke up with Big Bang Theory costar Johnny Galecki?